Which benzos are water soluble

In recent years, efforts have been made to formulate BZDs for nasal administration. Because of the low solubility of these molecules, organic vehicles have been used to solubilize the drugs in the nasal products under development.

However, organic solvents are irritating, potentially resulting in injury to nasal tissue. Clicking on the donut icon will load a page at altmetric. Find more information on the Altmetric Attention Score and how the score is calculated. The solubility of each drug increased exponentially with the addition of PEG and reached the maximum value in neat PEG The overall mean relative deviations of the models were 3. Data , 55 , 1 , View Author Information. E-mail: [email protected]. Cite this: J.

Data , 55 , 1 , — Article Views Altmetric -. Citations Cited By. This article is cited by 33 publications. Abdel-Kader , and Faiyaz Shakeel. No marked hangover effects are present the next morning. In anesthesiology, midazolam appears to be a useful, short-acting, sedative-anxiolytic and amnesic premedicant after both oral and parenteral administration.

In minor surgery, however, the slow, unpredictable onset and variable duration of action, as compared with thiopental, may inhibit its routine use as an induction agent, especially in young patients, without heavy premedication. In major surgery, midazolam is an alternative to thiopental for induction of anesthesia in spite of its slow, variable induction time.